Pyrimidines

Related Products of 6693-08-9, Adding some certain compound to certain chemical reactions, such as: 6693-08-9, name is 2,4,6-Trichloro-5-fluoropyrimidine,molecular formula is C4Cl3FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6693-08-9.

The thiophene (300 mg, 3.57 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL).After cooling to -15 C, n-butyllithium (1.4 mL, 3.57 mmol, 2.5 mol/L) was added.Stir at this temperature for 1 hour, then add ZnCl2-TMEDA (300 mg,1.18 mmol), stirring at room temperature for 1 hour, then adding palladium dichloride (65 mg, 0.36 mmol),Triphenylphosphine (188 mg, 0.71 mmol)And 5-fluoro-2,4,6-trichloropyrimidine (790 mg, 3.92 mmol),The resulting mixture was heated to 55 C under nitrogen to stir the reaction overnight.Water (50 mL) was added to the reaction mixture, and the mixture was evaporated.The combined organic phases were washed with brine (50 mL).Dry over anhydrous sodium sulfate, filter and concentrate under reduced pressure.The residue obtained is purified by silica gel column chromatography (pure petroleum ether).The title compound was obtained as a white solid(366 mg, 41%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
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Application of 944129-00-4, Adding some certain compound to certain chemical reactions, such as: 944129-00-4, name is Methyl 6-amino-2-chloropyrimidine-4-carboxylate,molecular formula is C6H6ClN3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944129-00-4.

6-Amino-2-chloropyrimidine-4-carboxylic acid methyl ester (2.25 g, 12 mmol, 4-chloro-2-fluoro-3-methoxyphenylboronic acid (3.27 g, 16 mmol), and bis(triphenylphosphine)palladium(II) dichloride (842 mg, 1.2 mmol) were combined in 12 mL of 1,2-dimethoxyethane and 12 mL of water. The reaction mixture was heated at 80 C. for 2 h and the cooled reaction mixture was partitioned between ethyl acetate and water. The organic phase was washed with water, dried, and concentrated under vacuum. The product was purified by flash chromatography on silica gel to yield the title compound (2.0 g, 53.5% yield): mp 188-190 C.: 1H NMR (CDCl3) delta 7.66 (dd, 1H), 7.22 (dd, 1H), 7.14 (s, 1H), 5.25 (br s, 2H), 4.0 (s, 3H), 3.99 (s, 3H).

According to the analysis of related databases, 944129-00-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dow AgroSciences LLC; US2009/88322; (2009); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 3680-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4ClN3, molecular weight is 153.5691, as common compound, the synthetic route is as follows.

Preparation 109; 4-Chloro-5-iodo-7H-pyrrolo|”2.3-Patent; ELI LILLY AND COMPANY; WO2008/140947; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23945-44-0, name is 2,4-Dihydroxypyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., Product Details of 23945-44-0

The starting material Compound G was introduced in the reactor with POC13 and about 3 equivalents of PC15. In this case POC13 acted as solvent due to the very low solubility of Compound G in many organic solvents. The reaction temperature was increased from 80 C to 105 C in 3 hrs and then left at 105 C for additional 1-2 hrs. When the reaction completed, POC13 was distilled. Toluene was added to the residue and distilled in order to reduce the amount of POC13. Crude Compound F-i was distilled at around 7-8 mbar, with ajacketed temperature of about 130-13 5 C. Average yield 72% and average purity 94.9 % by GC-FID.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 23945-44-0, 2,4-Dihydroxypyrimidine-5-carboxylic acid.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; PANDEY, Anjali; SRAN, Arvinder; CHEN, Ying; POGGIALI, Daniele; FUMAGALLI, Tiziano; (52 pag.)WO2019/213545; (2019); A1;,
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Related Products of 1074-41-5 ,Some common heterocyclic compound, 1074-41-5, molecular formula is C5H7N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 6-amino-2-(alkylthio)pyrimidin-4(3H)-one 5 (1 mmol),1,3-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione 6 (1 mmol),arylaldehyde (1 mmol) and [gamma-Fe2O3HAp-SO3H] (0.05 g) in EtOH (10 mL) was heated under reflux. The progress of the reaction was monitored by TLC (EtOAc/petroleum: 2/1). After completion ofthe reaction, the catalyst was separated from the reaction mixture by external magnet and reused in the next run. The reaction mixture was cooled, and the solid obtained was recrystallised from EtOH/H2O to give the desired pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1074-41-5, 6-Amino-2-(methylthio)pyrimidin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mamaghani, Manouchehr; Taati, Zahra; Rasoulian, Mona; Yousefizad, Javad; Toraji, Nooshin; Mohsenimehr, Mona; Nia, Roghayeh Hossein; Journal of Chemical Research; vol. 40; 1; (2016); p. 29 – 34;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5399-92-8, name is 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C5H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

To a stirred solution of 4-chloro-1H-pyrazolo[3,4-d]pyrimidine (0.2 g, 1.29 mmol) in anh THF (10 mL), 2-(piperidin-1-yl)ethanol (0.258 mL, 1.94 mmol) and triphenylphosphine (0.51 g ,1.94 mmol) were sequentially added. The reaction mixture was cooled to 0 C and diisopropylazodicarboxylate (0.38 mL ,1.94mmol) was added dropwise. The mixture was stirred for 30 min. at 0 C and kept overnight at 4 C. The solvent was removed at reduced pressure and the residue was dissolved in DCM and washed with diluted HCl 1N. The aqueous phase was separated, basified and extracted with DCM. The organic phase was separated, dried and the solvent was removed under reduced pressure to give a residue that was purified by flash chromatography eluting with (EtOAc/Petroleum ether, 8:2) to yield 4-chloro-1-(2-(piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidine (146 mg, 55 mmol, 42 %) as an oil that solidifies “on standing”.

With the rapid development of chemical substances, we look forward to future research findings about 5399-92-8.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; Diaz-Fernandez, Jose-Luis; Almansa, Carme; Corbera Arjona, Jordi; EP2733143; (2014); A1;,
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Pyrimidine – Wikipedia

Related Products of 799842-07-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799842-07-2, name is N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide. A new synthetic method of this compound is introduced below.

Example 3: Preparation of N-[4-(4-fluoro-phcnyl)-6-isopropyl-5-(4-mcthyl-4i1-[1,2,41 triazol-3-ylsulfanylmethyl)pyrimidin-2-yll -N-methyl-methane-sulfonamide Method A: To a solution of 4-methyl-4H-{l,2,4triazole-3-thiol (7.62g) in ethyl acetate (250ml), potassium carbonate (20g) was added and the reaction rnixtur was stirred for 30minutes at 25 to 30C. N-[5-Bromomethyl-4-(4-fluorophnyl)-6?-isopropylpyrimidin-2-yl]-N-methyl-methane sulfonamide (25g) was added and temperature was raised to 30 to 35C and stirred for 4 hours; After completion of reaction, the reaction mass was quenched with water (200m1). The organic-layer was separated and aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried on anhydrous sodium sulphate andconcentrated. Isopropyl ether (SUm) was added to the residue and stirred for 30 minutes at 25-30C and the resulting solid was filtered, washed with diisopropyl ether and dried to give (27g)of title compound which is characterizedby ?H-NMR and mass spectra.1H-NMR, (400 MHz, CDCI3, ppm): 1.34 (d, 6H), 3.50 (s, 4H), 3.53 (s, 6H), 4.50 (s, 2H), 7.12(dd, 2H), 7.65 (dd, 2H), 8.19 (s, 1H);Mass (M+1)45l amu

At the same time, in my other blogs, there are other synthetic methods of this type of compound,799842-07-2, N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide, and friends who are interested can also refer to it.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; NAIK RAJESH VINODRAI; JAIN ANSHUL KUMAR; SARIN GURDEEP SINGH; SAINI VINAY KUMAR; KUMAR VIJAY; WO2015/37018; (2015); A1;,
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Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 764659-72-5, name is (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate, the common compound, a new synthetic route is introduced below. Recommanded Product: 764659-72-5

To a 2.0 L capacity jacketed flask equipped with a mechanical stirrer, thermometer pocket, dipotassium hydrogen phosphate (147. lg) and water (330ml) was charged and stirred the reaction mixture for 15 minutes. To the reaction mixture then charged isopropyl alcohol (800ml) and further stirred for 15 minutes and cooled the reaction mixture to a temperature of 15C to 20C. Then charged FCME (lOOg) dissolved in isopropyl alcohol (100ml) to the reaction mixture and stirred at a temperature of 15C to 20C for 1 hour. A separately prepared solution of sodium borohydride (26g) dissolved in aqueous sodium hydroxide was added dropwise to the reaction mixture over the period of 1-1.5 hours. The reaction mixture further stirred for 4 – 5 hours and the two layers formed were separated. To the separated organic layer 20% (v/v) dilute hydrochloric acid (4.6ml) was added dropwise to adjust the pH to 8.0-8.5 and the reaction mixture was further stirred for 15 minutes. The reaction mixture was then distilled out and the aqueous solution obtained was extracted with toluene (200ml). The reaction mixture then treated with charcoal (5g) and filtered. The filtrate obtained was distilled out to obtain a liquid and diluted with isopropyl alcohol (200ml), distilled out the isopropyl alcohol. Diluted the reaction mixture again with isopropyl alcohol (200ml) and distilled out. The reaction mixture further diluted with isopropyl alcohol (400ml) and refluxed the reaction mixture to a temperature of 85C to 90C for 30 minutes to obtain the residue. Cooled the reaction mixture and filtered, the filtrate obtained was then distilled out to obtain the residue. Diluted the residue obtained with ethanol (100ml) and distilled out. The reaction mixture again diluted with ethanol (200ml) and heated at a temperature of 85C to 90C for 30 minutes and then cooled at a temperature of 10C to 15C to precipitate the product, emtricitabine. The resulting product was filtered and washed with ethanol. Dry the product under vacuum.Yield = 62%Assay = 98.7%Purity = 99.86%

The synthetic route of 764659-72-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMAL HEALTHCARE LIMITED; ROY, Mita; JAGTAP, Ashutosh; SHAH, Chirag; KUMBHAR, Ajay; HARIHARAN, Sivaramakrishnan; WO2012/131541; (2012); A1;,
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Application of 2927-71-1, Adding some certain compound to certain chemical reactions, such as: 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2927-71-1.

Step A: 2-Chloro-5-fluoropyrimidine To 2,4-dichloro-5-fluoropyrimidine (15.0 g, 89.8 mmol) is added tetrahydrofuran (100 mL) and zinc powder (17.6 g, 269 mmol). The mixture is heated to 70 0C with vigorous stirring, acetic acid (5.14 mL, 89.8 mmol) is added over Ih and the mixture is heated at reflux for an additional 5h. The mixture is diluted with dichloromethane, filtered through celite, evaporated in vacuo and purified on silica gel to give the desired product (6.00 g, 50 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/106705; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2972-52-3, 2,4-Dichloro-5-pyrimidinecarbonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2972-52-3, blongs to pyrimidines compound. SDS of cas: 2972-52-3

Step-1. Preparation of 2,4-dichloro-N-methylpyrimidine-5-carboxamide (2): To a solution of methyl amine (2M) in THF (2.4 mL, 4.70 mmol) in DCM (50 ml), TEA (963 mg, 9.50 mmol) and 2,4-dichloropyrimidine-5-carbonyl chloride (1 g, 4.70 mmol) were added slowly at -78 C. for 1 h. TLC showed completion of starting material (TLC system: 10% ethyl acetate in hexane (Rf): 0.3). The reaction mixture was diluted with DCM (50 ml), washed with water (2*30 ml) and a saturated solution of NaHCO3. The organic layer was separated, dried over sodium sulphate, and concentrated. Crude compound was purified by column chromatography using silica gel (100-200 mesh) with 5% ethyl acetate in hexane to obtain 2,4-dichloro-N-methylpyrimidine-5-carboxamide as white solid. Yield: (400 mg, 33%). 1HNMR (400 MHz, CDCl3) delta 8.98 (s, 1H), 6.50 (br s, 1H), 3.07 (d, 3H, J=4.8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2972-52-3, its application will become more common.

Reference:
Patent; Celgene Avilomics Research, Inc.; Haq, Nadia; Niu, Deqiang; Petter, Russell C.; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong; US2014/228322; (2014); A1;,
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