Pyrimidines

Related Products of 30129-53-4, Adding some certain compound to certain chemical reactions, such as: 30129-53-4, name is 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine,molecular formula is C6H5ClN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 30129-53-4.

The above (Example 1) (150 mg) was dissolved in acetonitrile (3.0 mL), N-bromosuccinimide (174 mg) was added thereto,And heated at 90 C. for 3 hours.The reaction solution was cooled to room temperature and concentrated under reduced pressure.The residue was diluted with ethyl acetate and the organic layer was washed successively with water and saturated brine, dried over sodium sulfate and concentrated.The obtained crude product was purified by silica gel column chromatography(Mobile phase; n-hexane: ethyl acetate = 100: 0-70: 30) to give the title compound (115 mg) as an off-white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30129-53-4, 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mochida Pharmaceutical Co., Ltd.; Nagasue, Hisashi; (86 pag.)JP2017/75116; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 823-89-2, 5-Bromo-2-hydrazinopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C4H5BrN4, blongs to pyrimidines compound. HPLC of Formula: C4H5BrN4

General procedure: Substituted chalcones (3) (0.001 mol), 5-bromo-2-hydrazinylpyrimidine (2) (0.001 mol) and 5 drops of glacial acetic acid was ground together in a mortar using a pestle for uniform mixing. This was taken in a 50 mL beaker and subjected to microwave irradiation (90 W). The completion of the reaction was confirmed by TLC. The product obtained was poured to crushed ice, filtered, dried and recrystallized from suitable solvent mixture to give pyrazolines 4a-l.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,823-89-2, 5-Bromo-2-hydrazinopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Adhikari, Adithya; Kalluraya, Balakrishna; Sujith, Kizhakke Veedu; Gouthamchandra, Kuluvar; Jairam, Ravikumar; Mahmood, Riaz; Sankolli, Ravish; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 467 – 474;,
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Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, molecular weight is 142.1127, as common compound, the synthetic route is as follows.Recommanded Product: 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

General procedure: 4.4.4. Method D (Na2CO3/DMF)Preparation of N-{[(4-hydroxy-3-nitrophenyl)carbamoyl]amino}-2,4,6-trioxo-1,3-diazinane-5-carboxamide (109). A mixtureof sodium bicarbonate (130 mg; 1.2 mmol), N,N-dimethylformamide(3 ml) and barbituric acid (256 mg 2.2 mmol) wassonicated for 1 h at 60 C. Into this solution the desired phenyl carbamate109bCF (603 mg; 2.2 mmol) was added. The reaction mixturewas sonicated at 100 C for 2 h followed by heating at 130 Cfor 2 additional hours. The reaction mixture was mixed with 5%hydrochloric acid (30 ml) and left to stir at room temperature for1 h. The formed precipitate was isolated via vacuum filtration,washed with water (3 30 ml), refluxed in ethanol (15 ml) for15 min, and then filtered to give the pure product (89%). 1H NMR(DMSO-d6, Agilent 400 MHz) d 11.15 (3H, br s), 10.59 (1H, s),9.42 (1H, br s), 9.30 (1H, s), 7.87 (1H, d, J = 8 Hz), 7.36 (1H, d,J = 4 Hz), and 7.08 (1H, d of d, J1 = 8 Hz, J2 = 4H) ppm. EMS (CH3-OH) m/z 365 (M1); M2 (366) m/z 366, 185 and 186.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2565-47-1, 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, and friends who are interested can also refer to it.

Reference:
Article; Hron, Rebecca J.; Jursic, Branko S.; Neumann, Donna M.; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6183 – 6193;,
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Pyrimidine – Wikipedia

Application of 163263-91-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.163263-91-0, name is 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine, molecular formula is C11H8Cl2N2O, molecular weight is 255.1, as common compound, the synthetic route is as follows.

2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine (1.01 g, 3.92 mmol)And (+/-)-trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester (1.02 g, 5.88 mmol)Dissolved in DMF (20 mL), then added potassium carbonate (0.81 g, 5.88 mmol).The reaction solution was stirred at 50 C overnight, and water (70 mL) was added.After dilution, extract with ethyl acetate (100 mL ¡Á 3).The combined organic phases were washed with brine (150 mL)Dry over anhydrous sodium sulfate, filter,The filtrate was concentrated under reduced pressure to dryness.The residue was purified by EtOAc EtOAc EtOAc (EtOAc)The title compound is white solid(1.01 g, 64%).

Statistics shows that 163263-91-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1558-17-4 ,Some common heterocyclic compound, 1558-17-4, molecular formula is C6H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To 10 mL of an aqueous 5N sodium hydroxide solution were added 0.21 g (2.0 mmol) of 4,6-dimethylpyrimidine, 1.1 g (4 mmol) of 4-methoxy-3-(4-methoxybenzyloxy)benzaldehyde, and 0.1 g (0.29 mmol) of tetrabutylammonium hydrogen sulfate, followed by heating under ref lux. The precipitate thus formed was filtered and washed with water. Then, it was dried in a vacuum drier and recrystallized in ethylacetate to afford 1.06 g of (E,E)-4,6-bis[4′-methoxy-3′-(4-methoxybenzyloxy)styryl]pyrimidine.1H NMR (DMSOd6, 400 MHz) delta 3.81 (s, 6H), 3.91 (s, 6H), 5.12 (s, 4H), 6.87 (d, J=15.9 Hz, 2H), 6.91 (d, J=8.6 Hz, 2H), 6.92 (d, J=8.5 Hz, 4H), 7.18 (d, J=8.6 Hz, 2H), 7.19 (s, 2H), 7.22 (s, 1H), 7.40 (d, J=8.5 Hz, 4H), 7.78 (d, J=15.9 Hz, 2H), 9.03 (s, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1558-17-4, 4,6-Dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; US2010/190803; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine. A new synthetic method of this compound is introduced below., category: pyrimidines

Cyclopropylamine (0.12 g) was added to a solution of 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine synthesised according to the method of (0.40 g) in ethanol (4.0 ml) at room temperature. The mixture was stirred at the same temperature overnight. The precipitated solid was separated by filtration and dried to obtain 6-chloro-N-cyclopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (yellow solid) (0.43 g, 97%). MS(ESI):210(M+H)+,208(M-H)- 1H NMR(300MHz,DMSO-D6)deltappm 0.55-0.73(m,2H),0.74-1.06(m,2H),2.97(bs,1H),8.18(bs,1H),8.51(bs,1H), 13.37(bs,1H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42754-96-1, 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.; EP2123654; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 56-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

a 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde Following the method of Bell et al. (J. Heterocyclic Chem. 1983, 20, 41), to 97.0 ml (1.06 mol) phosphorus oxychloride in a 2-necked flask cooled to 5 C. was added dropwise with stirring 32.5 ml (0.42 mol) DMF. The mixture was allowed to warm to room temperature and then 25.0 g (0.20 mol) 2-amino-4,6-dihydroxy-pyrimidine was added in small portions over 30 minutes. The reaction mixture was then heated at 100 C. for 4.5 hours before being poured cautiously onto water cooled to 10 C. and left standing at room temperature overnight. The resulting crystals were collected by filtration, and extracted with 4*450 ml hot ethyl acetate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one.

Reference:
Patent; Borroni, Edilio Maurizio; Huber-Trottmann, Gerda; Kilpatrick, Gavin John; Norcross, Roger David; US2001/27196; (2001); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 51940-64-8, Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 51940-64-8, blongs to pyrimidines compound. COA of Formula: C7H6Cl2N2O2

DIPEA (3.69 mL, 21.12 mmol) was added dropwise to ethyl2,4-dichloropyrimidine-5-carboxylate(3.89 g, 17.60 mmol) and tert-butyl (4-amino-1-methylcyclohexyl)carbamate (4.02 g, 17.6 mmol)in acetonitrile (80 mL) at 0C over a period of2 min. The reaction mixture was stirred at rt for 16 hand concentrated in vacuo. The resulting crude product was purified by fcc, elution gradient 0 to15 10% EtOAc in petroleum ether, to afford the title compound (6.0 g, 83%) as a pale yellow gum; 1HNMR (400 MHz, CDCb) 1.33 – 1.43 (6H, m), 1.43 – 1.64 (11H, m), 1.70 – 1.82 (lH, m), 1.85 -2.01 (4H, m), 2.17 (lH, s), 4.07-4.24 (2H, m), 4.30-4.42 (2H, m), 8.24- 8.57 (lH, m), 8.67 (lH,s); m/z MH+ 413.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51940-64-8, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; HOWARD, Martin, Richard; TING, Attilla, Kuan, Tsuei; (145 pag.)WO2019/238929; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28485-17-8, name is 5-Carbethoxyuracil, the common compound, a new synthetic route is introduced below. SDS of cas: 28485-17-8

Method for svnthesising A. Id; B.2a A.1*d A.1d; Caesium carbonate (1.77 g, 5.43 mmol) is suspended in 10 mL DMSO, combined with carboxylic acid ester B.l-lc (1.00 g, 5.43 mmol) and stirred for 10 min at 200C. Then methyl iodide (0.338 muL, 5.43 mmol) is added and the mixture is stirred for 16 h at 200C. The crude product is purified by RP chromatography and carboxylic acid ester B.l-ld (HPLC-MS: tRet. = 0.64 min; MS(M+H)+ = 199; method FEC3) is obtained.

The synthetic route of 28485-17-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; McCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7114; (2010); A2;,
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Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54368-61-5, name is Ethyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate, molecular formula is C7H5Cl2N3O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 54368-61-5

4) 15 g of ethyl 2,4-dichloro-5-nitro-6-pyrimidinecarboxylic acid, 10 g of palladium on carbon, 5 g of magnesium oxide,Add 150 ml of THF, hydrogenate for 7 hours, filter, and apply with palladium and carbon recovery.The filtrate was evaporated to dryness to obtain a crude product. Column chromatography5.5 g of ethyl 2-chloro-5-amino-6-pyrimidinecarboxylic acid was obtained, more than 98%,The yield was 48%.

With the rapid development of chemical substances, we look forward to future research findings about 54368-61-5.

Reference:
Patent; Nanjing Puruida Pharmaceutical Technology Co., Ltd.; Wang Xiaobo; (6 pag.)CN110452180; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia