Pyrimidines

Determination and occurrence of sulfonamide transformation products in surface waters was written by Cui, Hongyang;Chang, Hong;Zheng, Hongjin;Wan, Yi. And the article was included in Science of the Total Environment in 2021.Reference of 1220-83-3 This article mentions the following:

The transformation products of sulfonamides (SAs) have raised increasing environmental and health concerns in recent years, but information on their anal. and environmental fates remains limited. In this study, an anal. method using liquid chromatog. with tandem mass spectrometry (LC-MSMS) was optimized to simultaneously analyze 9 SA transformation products and 14 SAs in water samples. This method was applied to investigate the occurrence of antibiotics in three urban rivers in Beijing, and all of the target compounds were detected. N-acetylsulfamethoxazole, N-acetylsulfapyridine, and N-acetylsulfamethazine were found to be the predominant acetyl SAs in the aquatic environment, and high frequencies of hydroxylated SA (5-hydroxysulfapyridine) and glucuronide-conjugated SA (sulfamethoxazole 灏?D-glucuronide) were also detected. The SA transformation products accounted for 22-32% of the total concentrations of SAs and their transformation products in the water samples. The pollution levels of the compounds exerted only minor effects on the proportions of the SA transformation products. The compound-specific transformation of sulfamethoxazole, sulfapyridine, and sulfadiazine in the water samples was consistent with their acetylation efficiencies in metabolic processes in organisms, which suggests that the SA-acetylated products were derived mainly from biol. metabolism in humans or animals. This finding was supported by the fact that environmental degradation exerts a weak effect on SA profiles in the water samples. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Reference of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Reference of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

N-CQDs from reed straw enriching charge over BiO_2-x/BiOCl p-n heterojunction for improved visible-light-driven photodegradation of organic pollutants was written by Qi, Kemin;Ye, Yuping;Wei, Bin;Li, Mengxin;Lun, Yanxin;Xie, Xiaoyun;Xie, Haijiao. And the article was included in Journal of Hazardous Materials in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Green bismuth-based photocatalysts have attracted extensive attention in the field of PPCPs photodegradation The improved carrier separation efficiency still remains a key factor to enhance photocatalytic performance. Herein, N-doped biomass carbon quantum dots (N-CQDs) decorated p-n heterojunction photocatalyst BiO₂-x/BiOCl was prepared using a facile ion-etching strategy, and it displayed a markedly enhanced catalytic activity in the photodegradation of sulfonamide antibiotics. Calculated by the differential charge d., the doped N-CQDs could gather photogenerated electrons, which indicated that the introduction of N-CQDs into BiO₂-x/BiOCl would effectively inhibit the recombination of photogenerated charge carriers. In addition, photocatalytic performance and d. functional theory (DFT) calculation results revealed that the photogenerated electrons tended to transfer from p-BiOCl to n-BiO₂-x through N-CQDs, which could generate 璺疧₂^– and photogenerated h⁺ to oxidize the target pollutants. Benefiting from the synergistic effect of accelerated separation of e^–-h⁺ in p-n heterojunction and the electron-rich performance of N-CQDs, the superb TOC removal efficiencies (89.40% within 120 min visible-light irradiation) and toxicity reduction performance of photodegradation intermediates were achieved. As a consequence, this work will provide a design of high-quality photocatalysts and a green-promising strategy for bismuth-based photocatalysts in the water treatment of PPCPs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: synthesis, biological evaluation, and molecular modelling studies was written by Soares, Pedro;Costa, Raquel;Froufe, Hugo J. C.;Calhelha, Ricardo C.;Peixoto, Daniela;Ferreira, Isabel C. F. R.;Abreu, Rui M. V.;Soares, Raquel;Queiroz, Maria-Joao R. P.. And the article was included in BioMed Research International in 2013.Category: pyrimidines This article mentions the following:

The vascular endothelial growth factor receptor-2 (VEGFR-2) is a tyrosine kinase receptor involved in the growth and differentiation of endothelial cells that are implicated in tumor-associated angiogenesis. In this study, novel 1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas, e.g., I, were synthesized and evaluated for the VEGFR-2 tyrosine kinase inhibition. Three of these compounds showed good VEGFR-2 inhibition presenting low IC₅₀ values (150-199 nM) in enzymic assays, showing also a significant proliferation inhibition of VEGF-stimulated human umbilical vein endothelial cells (HUVECs) at low concentrations (0.5-1 娓璏), using the Bromodeoxyuridine (BrdU) assay, not affecting cell viability. The determination of the total and phosphorylated (active) VEGFR-2 was performed by western blot, and it was possible to conclude that the compounds significantly inhibit the phosphorylation of the receptor at 1 娓璏 pointing to their antiproliferative mechanism of action in HUVECs. The mol. rationale for inhibiting the tyrosine kinase domain of VEGFR-2 was also performed and discussed using mol. docking studies. In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Category: pyrimidines).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Solventless synthesis of the 2,2′-bipyrimidine derivatives was written by Cai, Chun;Lue, Chun-Xu. And the article was included in Yingyong Huaxue in 2004.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine This article mentions the following:

A non-solvent synthesis procedure for the preparation of 2,2′-bipyrimidine, 4,4′,6,6′-tetramethyl-2,2′-bipyrimidine and 4,4′, 6,6′-tetraphenyl-2,2′-bipyrimidine in high yields was developed using fresh copper powder as catalyst. In the experiment, the researchers used many compounds, for example, 2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine).

2-Bromo-4,6-dimethylpyrimidine (cas: 16879-39-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Application In Synthesis of 2-Bromo-4,6-dimethylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

One-Pot Sequential Synthesis of 2-Amino-4,6-Diaryl Pyrimidines Involving SO₃H-Functionalized Piperazinium-Based Dicationic Ionic Liquids as Homogeneous Catalysts was written by Saikia, Susmita;Borah, Ruli. And the article was included in ChemistrySelect in 2019.Related Products of 40230-24-8 This article mentions the following:

A new series of -SO₃H functionalized dicationic ionic liquids based on N,N,N’,N’-tetrasulfopiperazinium cation [TSPi]⁺ and various anions [X]^– (X = Cl, CF₃SO₃, TsO) was synthesized. Bronsted acidity of these ionic liquids was determined by Hammett plot using UV-Visible absorbance spectra. Further, they were examined as acidic catalysts for one-pot preparation of 2-amino-4,6-diarylpyrimidines I [R = H, 2-HO, 4-Cl, 2,4-Cl₂, etc.] through Biginelli-like reaction of acetophenone, benzaldehydes and urea followed by a condensation-aromatization reaction with phenylhydrazine under solvent-free grinding method. The most acidic catalyst, [TSPi][CF₃SO₃]₂, offered good to satisfactory yield within 15-25 mins reaction time. Easy recyclability and simple and mild reaction conditions represented the advantages of this method. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pteridines, LXIV. Synthesis and properties of thiolumazines was written by Southon, Ian W.;Pfleiderer, Wolfgang. And the article was included in Chemische Berichte in 1978.Application of 54030-56-7 This article mentions the following:

Thiolumazines I (R = Me, R¹ = H, Me, Ph, 2-pyridyl) were prepared in 82, 70, 50, and 8% yields by cyclizing diaminopyrimidine II with R¹COCOR¹. Cyclization of I (R = H, R¹ = H, Me, Ph) with Br(CH₂)_nBr (n = 2, 3) in aqueous N NaOH or DMF-K₂CO₃ gave preferentially, 44, 35, and 88% thiazolo- (III, R¹ = H, Me, Ph, n = 2) and 14 and 68% thiazinopteridines III (R¹ = H, Ph, n = 3), with the [3,2-a]isomers as minor products (thiazolopteridine IV was isolated in 5% yield). Stirring I (R = Me, R¹ = Me, Ph) with CH₂Br₂ and K₂CO₃ in DMF 4.5 h at 60鎺?gave 87 and 53% sulfide V (R¹ = Me, Ph; m = 1), whereas refluxing with THF 2 h gave 56 and 22% V (R¹ = Me, Ph; m = 0), 7% VI (R = R¹ = Me), and 11% pteridine VII. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Application of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis was written by Cousins, David L.;Fricero, Prisca;Kopf, Kenji P. M.;McColl, Elliot J.;Czechtizky, Werngard;Lim, Yee Hwee;Harrity, Joseph P. A.. And the article was included in Angewandte Chemie, International Edition in 2021.Category: pyrimidines This article mentions the following:

We report a novel and general method to access a highly understudied privileged scaffold – pyrimidines bearing a trifluoroborate at C4 (e.g., I) and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chem. is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C-B bond when suitably activated. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Category: pyrimidines).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

灏?Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease was written by Hilpert, Hans;Guba, Wolfgang;Woltering, Thomas J.;Wostl, Wolfgang;Pinard, Emmanuel;Mauser, Harald;Mayweg, Alexander V.;Rogers-Evans, Mark;Humm, Roland;Krummenacher, Daniela;Muser, Thorsten;Schnider, Christian;Jacobsen, Helmut;Ozmen, Laurence;Bergadano, Alessandra;Banner, David W.;Hochstrasser, Remo;Kuglstatter, Andreas;David-Pierson, Pascale;Fischer, Holger;Polara, Alessandra;Narquizian, Robert. And the article was included in Journal of Medicinal Chemistry in 2013.Reference of 38275-61-5 This article mentions the following:

An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pK_a and thereby dramatically change the pharmacol. profile of this class of BACE1 inhibitors. The CF₃ substituted oxazine 89, a potent and highly brain penetrant BACE1 inhibitor, was able to reduce significantly CSF A灏?0 and 42 in rats at oral doses as low as 1 mg/kg. The effect was long lasting, showing a significant reduction of A灏?0 and 42 even after 24 h. In contrast to 89, compound 1b lacking the CF₃ group was virtually inactive in vivo. In the experiment, the researchers used many compounds, for example, 5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5Reference of 38275-61-5).

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Reference of 38275-61-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Fates of antibiotic resistance genes during upgrading process of a municipal wastewater treatment plant in southwest China was written by Wang, Fan;Chen, Yangwu;Wang, Lin;Meng, Dan;Zhu, Rongxia;Li, Yong;Tan, Zhouliang;Deng, Qinwen. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Application of 1220-83-3 This article mentions the following:

This study comprehensively analyzed the fates of antibiotics, antibiotic resistance genes (ARGs) and microbial community during upgrading process of municipal wastewater treatment plant (MWTP) of Anaerobic/Anoxic/Oxic-membrane bioreactor (A2/O-MBR) from regulation to stable operation phase. The factors most affecting ARGs profile were investigated, and the potential hosts for ARGs were further determined Results showed that the removal rate of total antibiotics and the reduction of ARGs increased by 10.49% and 1.37 logs in A2/O-MBR during upgrading process, resp. The most prevalent ARG was sul1 in both water and sludge phase. Mobile genetic elements (MGEs) and microbial community were the most significant factors affecting ARGs distribution in water phase and sludge, resp. Notably, the abundance of potential antibiotic resistance bacteria (ARB) was significantly decreased during upgrading process. Therefore, sul1and intI1 proliferation as well as microbial community succession should be emphasized in ARGs pollution management and control. This study expected to provide a theor. basis for the application of MBR process to remove antibiotics and ARGs in upgrading of MWTPs. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Application of 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Application of 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Identification of indicator PPCPs in landfill leachates and livestock wastewaters using multi-residue analysis of 70 PPCPs: Analytical method development and application in Yangtze River Delta, China was written by Wu, Dongquan;Sui, Qian;Yu, Xia;Zhao, Wentao;Li, Qiang;Fatta-Kassinos, Despo;Lyu, Shuguang. And the article was included in Science of the Total Environment in 2021.COA of Formula: C11H12N4O3S This article mentions the following:

The source apportionment of pharmaceuticals and personal care products (PPCPs) in the water environment based on indicators (i-PPCPs) requires a comprehensive characterization of various emission sources using reliable anal. methods for a wide spectrum of PPCPs. In this study, a robust and sensitive method based on solid phase extraction (SPE) and ultra-high performance liquid chromatog. coupled with tandem mass spectrometry (UHPLC-MS/MS) for analyzing 70 PPCPs belonging to 17 therapeutic classes in landfill leachates and livestock wastewaters was developed. The SPE cartridges, sample pH, elution solvents and chelating agent additions were optimized, and acceptable recoveries (60- 130% for 67 target compounds), low method quantification limits (landfill leachate: 3- 1309 ng/L; livestock wastewater: 3- 686 ng/L) and high precisions (repeatability: 0- 20% for over 99% injections; reproducibility: 0- 20% for over 90% injections) were obtained. Using the optimized anal. method to characterize PPCPs in the typical landfill leachate and livestock wastewater in Yangtze River Delta, China, we found anthelmintics, which were first reported in landfill leachates globally, exhibited the highest concentration (albendazole, maximum concentration of 61.6娓璯/L), and therefore proposed albendazole as one of the promising i-PPCP candidates in landfill leachates. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3COA of Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.COA of Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia