Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor was written by Opoku-Temeng, Clement;Dayal, Neetu;Hernandez, Delmis E.;Naganna, N.;Sintim, Herman O.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Quality Control of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:
Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Quality Control of 2-Methoxypyrimidine-5-carbaldehyde).
2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 2-Methoxypyrimidine-5-carbaldehyde
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia