Related Products of 54660-78-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54660-78-5, name is 4-Chloropyrimidin-5-amine. A new synthetic method of this compound is introduced below.
A mixture of 4-chloropyrimidin-5-amine (8.0 g, 62 mmol), ethyl 2-oxopropanoate(14.4 g, 124 mmol) and p-toluenesulfonic acid monohydrate (0.90 g, 4.7 mmol) intoluene (100 mL) was stirred at reflux for 3 hours, while water was azeotropically removed with a Dean-Stark trap. The mixture was subsequently concentrated to a small volume and purified by silica gel chromatography (Gradient: 0percent to 30percent ethyl acetate in petroleum ether) to afford the product as a yellow solid. Yield: 2.1 g, 9.2 mmol, 15percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,54660-78-5, its application will become more common.
Reference:
Patent; PFIZER INC.; CHAPPIE, Thomas Allen; CHANDRASEKARAN, Ramalakshmi Yegna; HELAL, Christopher John; LACHAPELLE, Erik Alphie; PATEL, Nandini Chaturbhai; SCIABOLA, Simone; VERHOEST, Patrick Robert; WAGER, Travis T.; (202 pag.)WO2016/203347; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia