Adding a certain compound to certain chemical reactions, such as: 17180-94-8, 5-Chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloropyrimidine, blongs to pyrimidines compound. Application In Synthesis of 5-Chloropyrimidine
A solution of 5-chloropyrimidine (5 mmol) and MeONa (5.5 mmol) in THF (30 mL) was stirred overnight at 150 C. After cooling to rt, the solvent was removed and water (20 mL) was added to the residue. The resulting mixture was extracted with EtOAc (3 x 35 mL). The combined organic layers were washed with brine, and dried over anhydrous Na2S04. After filtration and concentration, the crude product was purified by column chromatography to give the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,17180-94-8, 5-Chloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; CAMPBELL, Una; HANANIA, Taleen, G.; SHAO, Liming; WO2013/119895; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia