Related Products of 36082-50-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 36082-50-5 as follows.
Step 1 1 mol/L Sodium hydroxide (150 mL) was added to mixture of 5-bromo-2,4-dichloropyrimidine (25 g, 110 mmol) and THF (50 mL), and stirred at room temperature for 3.5 hours, the reaction mixture was neutralized with 2 mol/L hydrochloride, and extracted with chloroform (150 mL). The organic phase was washed by saturated saline (100 mL), and dried over anhydrous magnesium sulfate. After concentrated in vacuo, the residue was added to chloroform and hexane, and the resulting powder was filtered to give 5-bromo-2-chloropyrimidin-4(3H)-one (6.15 g, yield: 27%) as white powder. 1H-NMR (delta ppm TMS/DMSO-d6): 8.37 (1H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36082-50-5, its application will become more common.
Reference:
Patent; Shionogi & Co., Ltd.; KAI, Hiroyuki; TANAKA, Satoru; HIRAMATSU, Yoshiharu; NOZU, Azusa; NAKAMURA, Ken’ichioh; (260 pag.)US2016/24072; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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