Application of 252723-17-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 252723-17-4, name is 5-Bromo-4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
A suspension of 7-Benzenesulfonyl-5-bromo-4-chloro-7H-pyrrolo [2,3- d] pyrimidine (4.9 g, 13 mmol), Piperazine-l-carboxylic acid tert-butyl ester (3.7g, 20 mmol), and DIPEA (5.7 mL, 33 mmol) in IPA (30 mL) was stirred and heated at reflux for 6 hours. The mixture was cooled to-10 C, the solids collected by vacuum filtration, rinsed with cold IPA and dried under vacuum to give 4- (7-Benzenesulfonyl-5-bromo-7H-pyrrolo [2,3- d] pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (5.9g, 86%. ) LCMS (APCI+) m/z 522 and 524 [M+H] + ; Rt: 3.92 min. 1H NMR (DMSO-d6,400 MHz) 5 8. 48 (1H, s), 8.21 (2H, d, J 8. 2 Hz), 7.66-7. 62 (2H, m), 7.54 (2H, t, J 7. 8 Hz), 3.62-3. 55 (8H, m), 1. 48 (9H, s.)
According to the analysis of related databases, 252723-17-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARRAY BIOPHARMA INC.; WO2005/51304; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia