Electric Literature of 6960-17-4 ,Some common heterocyclic compound, 6960-17-4, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In 2000ml four bottles in order to join4-Amino-2,5-dimethoxypyrimidine (116.7 g, 0.75 mol)And toluene (188 g),Heated to 70 ~ 75 ,A solution of phenoxycarbonyl isothiocyanate in toluene was added dropwise,About 1 hour drop finished,Continue to heat 2 hours,The reaction was monitored by HPLC.To room temperature,The filter cake was washed twice with 50 ml of ethanol and dried at 60 C to give the desired intermediate4- [4- (2,5-dimethoxypyrimidinyl)] – 3-ThioureaPhenyl ester234.9g, the content is 98.1%, the yield is up to 92.0%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6960-17-4, its application will become more common.
Reference:
Patent; Beijing Yingli Refinement Technology Development Co., Ltd; Hubei Huida Technology Development Co., Ltd; Ling, Yun; Yan, Wei; Huang, Bibo; (7 pag.)CN105294697; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia