Application of 149849-92-3 ,Some common heterocyclic compound, 149849-92-3, molecular formula is C5H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a suspension of 2-chloropyrimindine-4-carboxylic acid (500 mg, 3.15 mmol) and DMF(0.024 mL, 0.32 mmol) in DCM (30 mL) stirred under nitrogen at 0 C was added a 2 Msolution of oxalyl chloride (1.74 mL, 3.47 mmol) in DCM dropwise. The reaction minxturewas allowed to warm to rt and stirred for further 3 h at rt. The reaction minxture wasevaporated in vacuo to give a brown oil. This residue was dissolved in THF (20 mL) and MeOH was added (0.14 mL, 3.5 mmol) dropwise. The reaction minxture was stirred at rt under nitrogen for lh. The reaction minxture was evaporated in vacuo to afford methyl 2- chloropyrimindine-4-carboxylate (780 mg, 4.5 mmol, purity: 80 %, recovery: 143 %) as abrown oil. The compound was used in the next step without purification. LCMS (mlz) 173 and 175 (M+H), retention time: 1.86 mm, LC/MS Method 2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 149849-92-3, 2-Chloropyrimidine-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DAUGAN, Alain Claude-Marie; DONCHE, Frederic G.; FAUCHER, Nicolas Eric; GEORGE, Nicolas S.; (243 pag.)WO2018/92089; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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