Application of 17326-27-1 , The common heterocyclic compound, 17326-27-1, name is 2-Chloro-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde, molecular formula is C10H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
222.6mg (1mmol) 2- chloro-3-aldehyde-4-carbonyl methylpyridine -4H-9- [1,2-alpha] pyrimidine 5mL of absolute ethanol was added a solution of 484.7mg (4mmol ) phenethylamine, rt 12h, after the reaction was filtered, the solid washed thoroughly with ethanol to give a pale yellow solid 320.2mg, 78% yield.
The synthetic route of 17326-27-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Chinese Academy Of Sciences Beijing Genome Institute; Yang Caiguang; Liu Jiang; Luo Cheng; Guo Zhongqiang; Gong Shouzhe; Li Jiafei; Zheng Tong; Jiang Hualiang; (46 pag.)CN107141287; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia