As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H3Cl2N3
2,4-Dichloro-5H-pyrrolo [3,2-d] pyrimidine(600 mg, 3.19 mmol) was placed in a round bottom flask,N, N-dimethylformamide DMF (5 mL) was added to dissolve it,Methyl iodide (544 mg, 3.83 mmol) and cesium carbonate (520 mg, 1.60 mmol) were added successively and the reaction was stirred at room temperature for 24 h.Treatment: The reaction solution was added to water and extracted with ethyl acetate,The organic phase was collected, dried over anhydrous sodium sulphate, filtered off with suction and concentrated. A yellow solid. Yield: 91%.
With the rapid development of chemical substances, we look forward to future research findings about 63200-54-4.
Reference:
Patent; Zhengzhou University The First Affiliated Hospital; Kan Quancheng; Tian Xin; Zhang Xiaojian; Cheng Weiyan; Du Yue; Yang Zhiheng; Yuan Yongliang; (12 pag.)CN107312006; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia