The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. SDS of cas: 2927-71-1.
Mujumdar, Prashant;Sarnpitak, Pakornwit;Shetnev, Anton;Dorogov, Mikhail;Krasavin, Mikhail research published 《 Facile Pd-catalyzed amination of imidazolin-1-yl chloroazines under microwave irradiation: toward a new kinase-inhibitory chemotype》, the research content is summarized as follows. An imidazolinyl-azine moiety, constructed using a recently developed Buchwald-Hartwig-type arylation methodol., displays excellent chem. stability under subsequent microwave-assisted Pd-catalyzed amination with a range of N-nucleophiles. This finding extends the use of imidazolinyl-azines for a bioactive compound library design. The latter is exemplified herein by the discovery of micromolar kinase inhibitors. The title compounds thus formed included 2,4-bis(1H-imidazol-1-yl)pyrimidine derivatives and (imidazolyl)pyrazine derivatives and related substances. The synthesis of the target compounds was achieved by a reaction of imidazole derivatives, such as 2-(4,5-dihydro-1H-imidazol-2-yl)pyridine, 2-(2-furanyl)-4,5-dihydro-1H-imidazole, 2-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-1H-indole with (chloro)azine derivatives, such as 2,6-dichloropyrazine, 2,4-dichloro-5-fluoropyrimidine.
SDS of cas: 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia