The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Recommanded Product: Pyrimidin-2-amine.
Mouffok, Meryem;Abdelmalek, Ilham;Mesli, Abderrezzak;Moulay, Awatif Amaria research published 《 Investigation of Factors Affecting Particle Size Distribution and Sustained Release of a Water-Soluble Drug from Cellulose Derivatives Microspheres》, the research content is summarized as follows. Microspheres loaded by 2-aminopyrimidine (2-AP) and based on cellulose derivatives as polymeric matrixes: ethylcellulose (EC) and cellulose acetate butyrate (CAB), were prepared by double emulsion solvent evaporation method (w/o/w). The main objective of this research is to conceptualize the fabrication of new formulations with high encapsulation efficiency and a large range of size for a controlled drug release of a water-soluble drug. The effects of the process variables, namely, nature of the matrix, stirring speed, surfactant nature and concentration on the mean particle size and distribution, drug loaded, encapsulation efficiency and drug release were investigated. The microspheres were characterized by SEM, optical microscopy, FT-IR spectroscopy and the size and size distribution (δ) were determined SEM images showed spherical and porous microspheres with different structures. We have obtained systems with large ranges of size (d32, 45-219 μm with EC; d32, 37-160 μm with CAB using Polyvinyl alc. (PVA) as emulsifier; and d32, 294-779 μm with Tween 80) by modifying the process parameters. Furthermore, the mean diameter d32 and the dispersion can be controlled particularly by stirring speed of emulsion and the emulsifier nature and concentration The drug entrapment and encapsulation efficiency were improved by controlling certain factors, especially by using PVA as a stabilizer in the continuous phase, by increasing PVA concentration (2% PVA) and when using EC as a matrix. The drug release was established in simulated gastric medium at pH 1.2 and 37 °C by UV-Vis anal. to estimate the drug content. The kinetics results revealed that the drug release is governed by the diffusion mechanism and the release rate can be adjusted by varying the encapsulation factors that have a significant effect on the particle size and size distribution.
Recommanded Product: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia