On November 5, 2021, Michalak, Olga; Cmoch, Piotr; Les, Andrzej; Cybulski, Marcin; Krzeczynski, Piotr; Trzcinska, Kinga; Miszta, Przemyslaw; Mehta, Pakhuri; Filipek, Slawomir published an article.SDS of cas: 626-48-2 The title of the article was Unexpected Reaction Products of Uracil and Its Methyl Derivatives with Acetic Anhydride and Methylene Chloride. And the article contained the following:
New acetyl derivatives of uracil, 6-methyluracil, and thymine were obtained in the course of an unconventional synthesis in methylene chloride. It was shown that products with the acetyloxymethyl fragment are formed according to a mechanism different from that for products with the acetyloxyethyl group. In particular, for uracil it was proven that the reaction with Ac2O, TEA, and CH2Cl2 leads to 1-acetyloxymethyluracil, where the N1 substituent is composed of the -CH2- fragment that originated from CH2Cl2 and the 1-acetyloxy moiety from Ac2O. The reaction of uracil with Ac2O, TEA, CH2Cl2, and DMAP leads to an acetyloxyethyl derivative in which the -CH2-CH2- fragment originates from TEA and the 1-acetyloxy moiety from Ac2O. A possible mechanism for the formation of new compounds was suggested and supported by the d. functional theory/B3LYP quantum mech. calculations New compounds (39 in total, including seven deuterated) were fully characterized by NMR and high-resolution mass spectrometry techniques. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).SDS of cas: 626-48-2
The Article related to uracil thymine methyluracil acetic anhydride dichloromethane reaction, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.SDS of cas: 626-48-2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia