The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Application of C4H3BrN2.
Meitinger, Nicolas;Mengele, Alexander K.;Nauroozi, Djawed;Rau, Sven research published 《 Pyrimidine-Substituted Hexaarylbenzenes as Versatile Building Blocks for N-Doped Organic Materials》, the research content is summarized as follows. In this work the synthesis of several bis-pyrimidine substituted hexaarylbenzenes (HABs) such as I [R1 = H, t-Bu; R2 = H, t-Bu] furnished with tert-Bu groups at different sites of the four pendant Ph rings was reported. The synthetic procedure was based on modular [4 + 2]-Diels-Alder cycloaddition reactions followed by decarbonylation. Anal. of the solid-state structures revealed that the newly synthesized HABs feature a propeller-like arrangement of the six arylic substituents around the benzene core. Here, the tilt of the aryl rings with respect to the central ring strongly depends on the intermol. interactions between the HABs and co-crystallized solvent mols. Interestingly, by evading the closest proximity of the central ring using an alkyne spacer, the distant pyrimidine ring wais oriented in the coplanar geometry with regard to the benzene core, giving rise to a completely different UV-absorption profile.
Application of C4H3BrN2, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia