《5-Nitro-2,4-dichloropyrimidine as an universal model for low-energy electron processes relevant for radiosensitization》 was written by Luxford, Thomas F. M.; Pshenichnyuk, Stanislav A.; Asfandiarov, Nail L.; Perecko, Tomas; Falk, Martin; Kocisek, Jaroslav. Recommanded Product: 3934-20-1 And the article was included in International Journal of Molecular Sciences in 2020. The article conveys some information:
We report exptl. results of low-energy electron interactions with 5-nitro-2,4- dichloropyrimidine isolated in the gas phase and hydrated in a cluster environment. The mol. exhibits a very rare combination of many so far hypothesized low-energy electron induced mechanisms, which may be responsible for synergism in concurrent chemo-radiation therapy of cancer. In contrast to many previous efforts to design an ideal radiosensitizer based on one mode of action, the present model mol. presents an alternative approach, where several modes of action are combined. With respect to the processes induced by the low-energy electrons, this is not a trivial task because of strong bond specificity of the dissociative electron attachment reaction, as it is discussed in the present paper. Unfortunately, low solubility and high toxicity of the mol., as obtained from preliminary MTT assay tests, do not enable further studies of its activity in real biol. systems but it can advantageously serve as a model or a base for rational design of radiosensitizers. The results came from multiple reactions, including the reaction of 2,4-Dichloropyrimidine(cas: 3934-20-1Recommanded Product: 3934-20-1)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 3934-20-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia