On April 16, 2020, Liu, Shiqiang; Yuan, Yida; Bao, Meng; Huang, Shengai; Bao, Rudi published a patent.COA of Formula: C6H6ClN3O2 The title of the patent was Regulator of nitrogen-containing heteroaromatic derivatives, preparation method and application.. And the patent contained the following:
The invention disclosed a kind of regulator of nitrogen-containing heteroaromatic derivatives, their preparation method and application. The claimed compound is shown in structure I (W = CR4 or N; Q = CR5 or N; R4,R5 = H, D, alkyl, haloalkyl, etc.; L1 = bond, O, S, alkylene, alkenyl, etc.; L2 == bond , O or S; ring A = cycloalkyl, heterocyclo, aryl, heteroaryl, etc.; ring B = cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; R1 = H, D, alkyl, halo, etc.; R2 = H, D, halolakyl, amino, nitro, etc.; R3 = alkyl, alkenyl, alkynyl, etc.; x,y = 0, 1-5 integers). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used as protein tyrosine phosphatase-2C (SHP2) inhibitor, can be used for treating diseases or conditions such as Noonan syndrome, leopard skin syndrome, leukemia, neuroblastoma, melanoma, esophageal cancer, head and neck tumors, breast cancer, lung cancer and colon cancer, etc. , preferably non-small cell lung cancer, esophagus cancer and head and neck tumors. The experimental process involved the reaction of Methyl 6-amino-2-chloropyrimidine-4-carboxylate(cas: 944129-00-4).COA of Formula: C6H6ClN3O2
The Article related to heteroaromatic derivative preparation shp2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C6H6ClN3O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia