2-Amino- and 2-guanidino-4-thiazolylpyrimidines was written by Lipinski, Christopher A.;Craig, Rebecca H.;Wright, Roger B.. And the article was included in Journal of Heterocyclic Chemistry in 1985.SDS of cas: 75833-38-4 This article mentions the following:
Synthesis of the four amino- and guanidinothiazolylpyrimidines I [R,R1 = NH2, NHC(:NH)NH2] is described and pKa values are calculated Guanidinopyrimidines are more basic than guanidinothiazoles. However, the reverse is true of the amino heterocycles; the aminothiazole is more basic than the aminopyrimidine. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4SDS of cas: 75833-38-4).
2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 75833-38-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia