Study on the synthesis of 5-bromopyrimidine derivatives was written by Li, Gangyue;Zhang, Jie;Yan, Shenggang;Jiang, Shan. And the article was included in Guangdong Huagong in 2009.Synthetic Route of C10H7BrN2O This article mentions the following:
A method for the synthesis of the title compounds [i.e., 5-bromo-2-(phenoxy)pyrimidine derivatives] is reported here. Said target compounds were prepared by a reaction of 5-bromo-2-chloropyrimidine with phenol derivatives The substituent effects (electronic effect, steric effect and position of substituted groups) on the benzene ring were investigated. The results showed that the size of substituents had a significant effect on the product yield. The process has advantages, such as mild reaction conditions and simple operation. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4Synthetic Route of C10H7BrN2O).
5-Bromo-2-phenoxypyrimidine (cas: 257280-25-4) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Synthetic Route of C10H7BrN2O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia