Kwong, Cecil D.’s team published research in Bioorganic & Medicinal Chemistry Letters in 22 | CAS: 56-05-3

Kwong, Cecil D. published the artcileNovel substituted pyrimidines as HCV replication (replicase) inhibitors, Computed Properties of 56-05-3, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(2), 1160-1164, database is CAplus and MEDLINE.

(Pyrimidinylamino)dihydroxycyclopentanemethanols I [R = Ph, 2-ClC₆H₄, 3-ClC₆H₄, 4-ClC₆H₄, 2-FC₆H₄, 3-FC₆H₄, 4-FC₆H₄, 3-NCC₆H₄, 4-NCC₆H₄, 3-O₂NC₆H₄, 4-O₂NC₆H₄, 4-MeC₆H₄, 2-MeOC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, 4-F₃CC₆H₄, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 2-(MeO₂C)C₆H₄, 2-(EtO₂C)C₆H₄, 2-(Me₂CHO₂C)C₆H₄, 2-(H₂NCO)C₆H₄, 4-(H₂NCO)C₆H₄, 2-(EtNHCO)C₆H₄, 2-(MeSO₂)C₆H₄, 4-(MeSO₂)C₆H₄, 2-(H₂NSO₂)C₆H₄, 2-thiazolyl, 2-thienyl, 3-thienyl, 2-imidazolyl, 2-methoxycarbonyl-3-pyridinyl, 2-(ethoxycarbonyl)-3-pyridinyl, 2-methyl-3-pyridinyl, 4-methyl-3-pyridinyl, 2,4-dimethyl-3-pyridinyl, 4-methoxy-3-pyridinyl, 4-ethoxy-3-pyridinyl, 4-methoxy-2-methyl-3-pyridinyl, 4-ethoxy-2-methyl-3-pyridinyl; X = N:N, CH:CH, CH₂CH₂, 1,2-cyclopropanediyl, CC] are prepared as carbanucleoside analogs for use as inhibitors of hepatitis C virus replication; their inhibition of hepatitis C virus replication and their cytotoxicities were determined I [R = 2-(EtO₂C)C₆H₄, 3-thienyl; X = CC] had acceptable replicon potency, selectivity and in vivo oral pharmacokinetics in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Computed Properties of 56-05-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia