Krchnak, V. published the artcilePreparation and some reactions of 2,5-substituted pyrimidines, Synthetic Route of 56621-93-3, the publication is Collection of Czechoslovak Chemical Communications (1975), 40(5), 1384-9, database is CAplus.
The title compounds I (X = H, NH2, SH, SMe) were prepared by direct synthesis from [Me2NCH:C(CH:NMe2)N:CHNMe2]+ClO4- and HN:CXNH2. The reactants were reluxed in EtOH with dropwise addition of MeONa and HNEt2 distilled off in vacuo. I (X = H) was accompanied by [Me2NCH:NCH:NMe2]+ClO4- as by-product formed by reaction of liberated HNMe2 with HN:CHNH2. I (X = SMe) gave with NaClO, according to the reaction temperature, I (X = SOMe) or I (X = SO2Me) (II). II was especially ready for nucleophilic substitution of the SO2Me group and gave with alc. MeONa and with KCN in hot DMF, resp., I (X = OMe) and I (X = CN). Reaction of I (X = SH) with Me2SO in the presence of H2SO4 yielded III instead of the expected 2-hydroxypyrimidine derivative The readiness of II to undergo nucleophilic substitution by OMe and CN in the position 2 was compared with 3 addnl. 2-methylsulfonylpyrimidine 5-substituted with NHCHO, NH2, and H. The reaction rate was lowered by electron donating 5-substituents but the order of reactivities was different for OMe and CN.
Collection of Czechoslovak Chemical Communications published new progress about 56621-93-3. 56621-93-3 belongs to pyrimidines, auxiliary class Pyrimidine,Nitrile,Amine, name is 5-Aminopyrimidine-2-carbonitrile, and the molecular formula is C5H4N4, Synthetic Route of 56621-93-3.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia