Related Products of 86443-51-8On May 31, 2017, Jarusiewicz, Jamie A.; Jeon, Jae Yoon; Connelly, Michele C.; Chen, Yizhe; Yang, Lei; Baker, Sharyn D.; Guy, R. Kiplin published an article in ACS Omega. The article was 《Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia》. The article mentions the following:
Profiling of the kinase-binding capabilities of an aminopyrimidine analog detected in a cellular screen of the St. Jude small-mol. collection led to the identification of a novel series of FMS-like tyrosine kinase 3 (FLT3) inhibitors. Structure-activity relationship studies led to the development of compounds exhibiting good potency against MV4-11 and MOLM13 acute myelogenous leukemia cells driven by FLT3, regardless of their FLT3 mutation status. In vitro pharmacol. profiling demonstrated that compound 5e shows characteristics suitable for further preclin. development. The experimental process involved the reaction of 2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Related Products of 86443-51-8)
2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 86443-51-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia