Introduction of a new synthetic route about Synthetic Route of 89466-42-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89466-42-2, 4-Chloro-6-methoxy-2-(methylthio)pyrimidine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 89466-42-2 ,Some common heterocyclic compound, 89466-42-2, molecular formula is C6H7ClN2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 4-CHLORO-6-METHOXY-2-METHYLSULFANYL-PYRIMIDINE (900 MG), KF (274 mg), K2CO3 (1. 3 gram) and L-LEUCINOL (830 mg) in DMSO (20 ml) was stirred at 100C for 3 days. The solution was taken up in water, and extracted three times with ethyl acetate. The ethyl acetate layers were combined, washed with brine, dried over magnesium sulfate, filtered, and the solvents were removed in vacuo. Silica gel chromatography (heptane/ethyl acetate 3/1) provided 747 mg of the title compound. MS (m/z) 272 [M+H] + .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89466-42-2, 4-Chloro-6-methoxy-2-(methylthio)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2004/63192; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia