Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29509-91-9, name is 4-Chloro-2,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below., Product Details of 29509-91-9
4-Chloro-2.6-diphenylpyrimidine (10.00g, 37.49mmol), 4′-bromo-4-biphenylboronic acid (10.34g, 37.35mmol), tetrakis (triphenylphosphine) palladium (2.15g, 1.87 mmol), potassium carbonate (10.32g, 74.70mmol), tetrabutylammonium chloride (0.43g, 1.86mmol), toluene (80mL), ethanol (40mL) and deionized water (20mL) were added to a round bottom flask, and nitrogen The temperature was increased to 78 C under protection and stirred for 10 hours. The reaction solution was cooled to room temperature, and toluene (300 mL) was added for extraction. The organic phases were combined, dried over anhydrous magnesium sulfate, filtered, and the solvent was removed under reduced pressure. The alkane was purified by silica gel column chromatography as a mobile phase, and then recrystallized from a dichloromethane / ethyl acetate system to obtain a white solid intermediate IF-1 (12.18 g, yield 84%).
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Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Ma Tiantian; Yang Min; Nan Peng; (69 pag.)CN110615759; (2019); A;,
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