A common compound: 1722-12-9, name is 2-Chloropyrimidine,molecular formula is C4H3ClN2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 1722-12-9
General procedure: The Buchwald-Hartwig amination reaction under microwave irradiation was conducted in a CEM Discover apparatus. A 10-mL Teflon vessel was charged with 1.0 mmol of hetero-aryl halide, 3.0 mmol of amine, 2.0 of mmol base, 0.05 mmol of Pd(OAc)2 , 0.10 mmol of LHX, and 2.0 mL of solvent. The mixture was irradiated at 150 W at 100 C for the specified time and then allowed to cool. The reaction mixture was extracted 3 times with diethyl ether, and the combined organic extracts were washed with water, dried (MgSO4) , and evaporated to dryness. Purification of the residue by flash chromatography on silica gel afforded the pure products.
With the rapid development of chemical substances, we look forward to future research findings about 1722-12-9.
Reference:
Article; Yang, Liangru; Bian, Huanyu; Mai, Wenpeng; Mao, Pu; Xiao, Yongmei; Wei, Dong; Qu, Lingbo; Turkish Journal of Chemistry; vol. 39; 1; (2015); p. 121 – 129;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia