Electric Literature of 157335-93-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below.
Preparation of (4,6-Dimethyl-pyrimidin-5-yl)-(hexahydro-pyrrolo[3,4-clpyrrol-2- yl)-methanone (38, Ar2 = 4,6-dimethyl-pyrimidin-5-yl)To a mixture of 4,6-dimethyl-pyrimidine-5-carboxylic acid (0.85 g, 5.58 mmol, T. J. Kress et. al. Heterocydes 1994 38:1375) and 16a ( 1.13 g, 5.58 mmol, C. J. Ohnmacht et al. /. Heterocyd. Chem. 1983 20:321) in DCM (25 mL) at RT was added sequentially EDCI ( 1.43 g, 6.7 mmol), HOBt (0.9 g, 6.7 mmol) and DIPEA (3.9 mL, 22.34 mmol) and the mixture was stirred overnight at RT. The reaction mixture was washed with 5% NaHC?3 solution, dried (MgSO4) and concentrated in vacuo. The crude product was purified by flash chromatography on silica gel eluting with MeOH (containing 10% NH4OH) /DCM (0 to 4%) to afford 1.5 g of (5-benzyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6- dimethyl-pyrimidin-5-yl)-methanone: ms (ES+) m/z 337 (M + H) +.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; LEMOINE, Remy; MELVILLE, Chris Richard; ROTSTEIN, David Mark; WANNER, Jutta; WO2008/34731; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia