Synthetic Route of 1004-39-3 ,Some common heterocyclic compound, 1004-39-3, molecular formula is C4H6N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EB1 Schiff base was synthesized by reaction of 30mL of ethanol hot solution (60 C) of bisaldehyde (2,2?-(ethane-1,2-diylbis(oxy))dibenzaldehyde) (1 g, 3.7¡Á10-3mole) and 30 mL hot ethanol solution (60 C) of (hydrazine carbothioamide) (0.674 g, 7.4¡Á10-3mole) in ratio (1:2). In preparation of L1 Schiff base 30 mL of ethanol hot solution (60 C) of bisaldehyde (2,2?-(ethane-1,2-diylbis(oxy))dibenzaldehyde) (1 g, 3.7¡Á10-3mole) was mixed with 30 mL hot ethanol solution (60 C) (4,6-diaminopyrimidine-2-thiol) (0.525 g, 3.6¡Á10-3mole) in ratio (1:1). Then sulfuric acid was added to eliminate water through condensation, and then the reaction mixture was left under reflux for 2 h. The formed solid Schiff?s bases were separated by filtration and purified by crystallization from ethanol. This preparation can be summarized in the following Scheme 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.
Reference:
Article; Zayed, Ehab M.; Zayed; El-Desawy; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 134; (2015); p. 155 – 164;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia