On May 5, 2022, Hallur, Gurulingappa; Madhyastha, Naveena; Stephen, Michael Rajesh; Roth, Bruce; Pandey, Anjali; Saxton, Tracy; Rajagopal, Sridharan; Sadhu M., Naveen published a patent.COA of Formula: C4BrCl3N2 The title of the patent was Pyrimidine compounds, compositions, and medicinal applications thereof. And the patent contained the following:
The disclosure relates to a class of pyrimidine compounds of formula I (wherein X is NH and O; R1 is (C(R4)2)nR5; n = 0 – 3; each R4 is independently H, halo, OH, etc.; R5 is C4-10 cycloalkyl, aryl and heteroaryl; R2 is aryl, heteroaryl, cycloalkyl, etc.; R3 is substituted heteroaryl) and pharmaceutically acceptable salts, and stereoisomers thereof as EGFR inhibitors; their preparation and use to treat cancer. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their anticancer activities (some data given). The experimental process involved the reaction of 5-Bromo-2,4,6-trichloropyrimidine(cas: 63931-21-5).COA of Formula: C4BrCl3N2
The Article related to pyrimidine preparation egfr inhibitor anticancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C4BrCl3N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia