Gorai, Ananta published the artcileThiazole Containing PNA Mimic Regulates c-MYC Gene Expression through DNA G-Quadruplex, Application In Synthesis of 186046-81-1, the publication is Bioconjugate Chemistry (2022), 33(6), 1145-1155, database is CAplus and MEDLINE.
Peptide nucleic acids (PNAs), besides hybridization to complementary DNA and RNAs, bind and stabilize DNA secondary structures. Herein, we illustrate the design and synthesis of PNA like scaffolds by incorporating five membered thiazole rings as modified bases instead of nucleobases and their subsequent effects on gene regulation by biophys. and in vitro assays. A thiazole modified PNA trimer selectively recognizes c-MYC G-quadruplex (G4) DNA over other G4s and duplex DNA. It displays high stabilization potential for the c-MYC G4 DNA and shows remarkable fluorescence enhancement with the c-MYC G4. It is flexible enough to bind at 5′ and 3′ ends as well as in the groove region of c-MYC G4. Furthermore, the PNA trimer easily permeates cellular membrane and suppresses c-MYC mRNA expression in HeLa cells by targeting the promoter G4. This study illuminates modified PNAs as flexible mol. tools for selective targeting of noncanonical nucleic acids and modulating gene function.
Bioconjugate Chemistry published new progress about 186046-81-1. 186046-81-1 belongs to pyrimidines, auxiliary class Pyrimidine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(4-(((benzhydryloxy)carbonyl)amino)-2-oxopyrimidin-1(2H)-yl)acetamido)acetic acid, and the molecular formula is C39H35N5O8, Application In Synthesis of 186046-81-1.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia