《Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane》 was written by Fan, Tingting; Guo, Weikai; Shao, Ting; Zhou, Wenbo; Hu, Pan; Liu, Mingyao; Chen, Yihua; Yi, Zhengfang. Application of 3934-20-1 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:
A series of phenylthiazole and phenylthiophene pyrimidindiamine derivatives l [R1 = ethylamino, propylamino, butylamino, pyrrolidino; R2 = H, OMe, F, Cl, Br, etc.] were designed and synthesized by modifying the hit compound (N2-isobutyl-N4-((4-methyl-2-phenylthiazol-5-yl)methyl) pyrimidine-2,4-diamine) and their antibacterial activities were evaluated both in-vitro and in-vivo was reported. Among the tested compounds, compound I [R1 = isobutylamino; R2 = 3-bromo] displayed the best antibacterial activities, which was not only capable of inhibiting E. coli and S. aureus growth at concentrations as low as 2 and 3μg/mL in-vitro, but also efficacious in a mice model of bacteremia in vivo. Unlike conventional antibiotics, compound I [R1 = isobutylamino; R2 = 3-bromo] was elucidated to mainly destroy the bacterial cell membrane, with the dissipation of membrane potential and leakage of contents, ultimately leading to cell death. The destruction of cell structure was challenging to induce bacterial resistance, which suggested that compound I [R1 = isobutylamino; R2 = 3-bromo] was a promising alternatives to antibiotics against bacteria. The experimental part of the paper was very detailed, including the reaction process of 2,4-Dichloropyrimidine(cas: 3934-20-1Application of 3934-20-1)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application of 3934-20-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia