Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 591-12-8, is researched, SMILESS is O=C1OC(C)=CC1, Molecular C5H6O2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov’t, Non-P.H.S., Organic Letters called Construction of Enantioenriched γ,γ-Disubstituted Butenolides Enabled by Chiral Amine and Lewis Acid Cascade Cocatalysis, Author is Yu, Chenguang; Ji, Peng; Zhang, Yueteng; Meng, Xiang; Wang, Wei, the main research direction is butenolide preparation enantioselective regioselective chemoselective; alkynoic acid aldehyde tandem cyclization amine Lewis catalyst.COA of Formula: C5H6O2.
A cascade cocatalysis strategy for the facile construction of chiral γ,γ-disubstituted butenolides I (R1 = Me, Et; R2 = Ph, 1-naphthyl, 2-furyl, etc.) has been described. The synthetic manifold employs simple alkynoic acids R1CCCH2C(O)2H instead of the preformed silyloxy furans or 5-substituted furan-2(3H)-ones II. In situ formed 5-substituted furan-2(3H)-ones II by AgNO3 or Ph3PAuCl/AgOTf catalyzed cyclization of alkynoic acids can smoothly engage in the subsequent chiral diphenylprolinol TMS-ether catalyzed Michael and Michael-aldol reactions. The cascade process serves as a general approach to chiral quaternary γ,γ-disubstituted butenolides I.
From this literature《Construction of Enantioenriched γ,γ-Disubstituted Butenolides Enabled by Chiral Amine and Lewis Acid Cascade Cocatalysis》,we know some information about this compound(591-12-8)COA of Formula: C5H6O2, but this is not all information, there are many literatures related to this compound(591-12-8).
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia