Application of 5018-38-2 , The common heterocyclic compound, 5018-38-2, name is 4,6-Dichloro-5-methoxypyrimidine, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 14 4-(6-chloro-5-methoxy-pyrimidin-4-yl)-piperazin-1-carbaldehyde 17.9 g (0.1 mol) of 4,6-dichloro-5-methoxypyrimidine, 11.4 g (0.1 mol) of 1-piperazinylcarboxaldehyde and 13.8 g (0.1 mol) of potassium carbonate in 150 ml of acetonitrile were stirred at 20C for 48 hours. The reaction mixture was concentrated to dryness, 100 ml of distilled water were added, followed by extraction with con 3 x 100 ml of CH2Cl2. The extracts were dried and concentrated. 24.3 g (94.7%) of a white solid were yielded. 1H-NMR: (CDCl3, ppm): 8.22 (s, 1H); 8.12 (s, 1H) 3.95-3.82 (s.c., 4H); 3.79 (s, 3H); 3.65 (s.c, 2H); 3.50 (s.c., 2H)
The synthetic route of 5018-38-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VITA-INVEST, S.A.; EP714896; (1996); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia