Extracurricular laboratory: Synthetic route of 4-Chloro-5-methylfuro[2,3-d]pyrimidine

With the rapid development of chemical substances, we look forward to future research findings about 1321618-96-5.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1321618-96-5, name is 4-Chloro-5-methylfuro[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-Chloro-5-methylfuro[2,3-d]pyrimidine

To a solution of 4-chloro-5-methylfuro[2,3-d]pyrimidine (12, 85 mg, 0.5 mmol) and 4-methoxy-N-methylaniline (5, 80 mg, 5.75 mmol) in 2 mL of anhydrous isopropanol (IPA) added 2 drops of concentrated HC1 and the reaction mixture was stirred at room temperature overnight. The brown precipitate was collected by filtration, washed with cold isopropanol, and dried under vacuum to afford compound 2 (95 mg, 75 %) as brown solid. Analytical data of compound 2 is identical with the product obtained using previous method.12

With the rapid development of chemical substances, we look forward to future research findings about 1321618-96-5.

Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; KUMAR, Dileep; MANN, J., John; (109 pag.)WO2019/89575; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia