Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36314-98-4, name is 2-Amino-4-cyanopyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Amino-4-cyanopyrimidine
Step 2: Synthesis of 1-37.2To a solution of 1-37.1 (100 mg, 0.83 mmol) in CH3CN (10 mL) is added NBS (222 mg, 1.2 mmol) at room temperature. The solution is stirred at the same temperature for 12 hours. The solution is concentrated and the residue is purified by silica gel flash column chromatography with 10% MeOH in CH2C12 as the eluent to afford 1-37.2 (100 mg); m/z: 200 [M++l]
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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John, D.; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/40137; (2012); A1;,
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