Application of 831203-15-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 2- (5-bromopyrimidin-2-yl) acetonitrile (0.1 (^, 0.50%)4-fluorophenylboronic acid (0.088, 0.601111111)Potassium carbonate (0.21 g, 1.50 mmol),Tetrakis (triphenylphosphine) palladium (0.3 g, 0.30 mmol)And toluene (10 mL) were successively added to a 50 mL reaction flask,The reaction was carried out with nitrogen and the reaction was carried out at 100 C for 8 hours.The reaction was quenched and the solvent was removed by distillation under reduced pressure. The remaining solid was extracted with dichloromethane (10 mL X), washed with organic phase, saturated brine (20 mL) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The title compound (white solid, 0.088, 80.1%) was obtained by silica gel column chromatography (petroleum ether / acetone (nu / nu) = 20/1)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Wei Dehuo; Xue Yaping; Zhang Yingjun; (44 pag.)CN106674207; (2017); A;,
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