Electric Literature of 62208-68-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 62208-68-8 as follows.
Intermediate I-3 (20 g, 98.9 mmol)Dissolve in a 500 mL round bottom flask with 300 mL of phosphorus oxychloride.Cool down to -30 C,N,N-Diisopropylethylamine (25.6 g, 0.2 mol) was added slowly.The mixture was stirred under reflux for 36 hours, and then cooled to room temperature.The reaction solution was poured into ice water and extracted with ethyl acetate.The extracted organic phase is washed with a saturated sodium hydrogen carbonate solution.And remove water with sodium sulfate.The treated organic phase was concentrated to dryness to give Intermediate I-4 (10.6 g, 45%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62208-68-8, its application will become more common.
Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Huang Dong; Hua Wanming; Quan Meizi; Zhao Xiaoyu; (34 pag.)CN109678868; (2019); A;,
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