In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, the common compound, a new synthetic route is introduced below. name: 4,6-Dichloro-2-methylpyrimidin-5-amine
Preparation 1 6-Chloro-N*4*-(4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine; 4,6-dichloro-2-methyl-pyrimidin-5-ylamine (985.3 g, 5.53 MoI) was added with stirring to a 2OL reactor charged with EtOH (4.0 L) over 3 minutes to give complete solution. p-Anisidine (718.0 g, 5.83 MoI) was then added with stirring over 3 minutes. A dark brown solution was observed and addition of both reagents gave an exotherm of 130C. EtOH (1 L) was then added followed by a premixed solution of c.HCI (0.5 L) in EtOH (2 L) at a steady rate over 40 minutes. A slight exotherm up to approx 2O0C was noted. The solution was then warmed to 8O0C and held at that temperature for 3.5 hours during which a grey precipitate appeared. Heating was continued for a further 2 hours then the temperature was reduced to 490C, and stirring was continued for 19 hours. The reaction mixture was allowed to cool to 3O0C, before draining out of 2OL reactor. The reaction mixture was filtered to collect a beige precipitate. Washed with EtOH (2.5 L), the MTBE (2.5 L) and sucked dry under N2(g) for 22 hours. The filter cake was then dried under vacuum at 5O0C for 60 hours, to yield title compound, as the hydrochloride salt, as a beige solid (1.465 Kg, 88%). 1H NMR (400MHz, DMSO-d6) delta = 2.27 (s, 3H), 3.71 (s, 3H), 6.90 (d, 2H), 7.58 (d, 2H), 9.10 (bs, 1 H). LCMS (System 4): 2.4 mins m/z (APCI) 265 [MH+]
The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia