Electric Literature of 31575-35-6 ,Some common heterocyclic compound, 31575-35-6, molecular formula is C4H3FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 182 N-(3-Chloro-4-fluorophenyl)-N’-hydroxy-2-((pyrimidin-2-ylamino)methyl)-1H-imidazo[4,5-b]pyridine-7-carboximidamide A solution of (7-(4-(3-chloro-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1-(methylsulfonyl)-1H-imidazo[4,5-b]pyridin-2-yl)methyl methanesulfonate (59 mg, 0.114 mmol) in acetonitrile (3 mL) was treated with ammonia (0.5 M solution in dioxane, 1.9 mL, 0.97 mmol) and stirred at room temperature overnight. The solution was then divided into two batches of equal volume. One of the batches was concentrated under reduced pressure and the resulting residue taken up in DMSO (1 mL). The solution was treated with N,N-diisopropylethylamine (0.061 mL, 0.35 mmol) followed by 2-fluoropyrmidine (23 mg, 0.23 mmol) and stirred for at room temperature for 48 h. The mixture was then treated with water (1 mL) and 2 M sodium hydroxide (0.5 mL) and stirred for 15 min, then acidified acetic acid, diluted with dimethyl sulfoxide, and purified by reverse phase preparative HPLC to provide the desired product. C18H14ClFN8O. 413.1 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 31575-35-6, 2-Fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Gilead Sciences, Inc.; Bartlett, Mark J.; Codelli, Julian Andrew; Corkey, Britton Kenneth; Cosman, Jennifer Leigh; Elbel, Kristyna; Loyer-Drew, Jennifer Alissa; Sperandio, David; Van Veldhuizen, Joshua; Yang, Hai; Yeung, Suet Chung; (251 pag.)US2016/333009; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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