Reference of 312613-82-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 312613-82-4, name is Pyrimidine-2-carboximidamide acetate, molecular formula is C7H10N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a dry, IL round bottom flask 845 ml of methanol was taken. To this 16 g sodium metal was added at room temperature till it was dissolved, under cooling to obtain sodium methoxide. 98.23 g of diethyl-2-(2-methoxy phenoxy) malonate (0.34 mole) was added into it and stirred at room temperature for 30 min to 1 hrs and subsequently added 65 g pyrimidine-2-carboxamidine (0.23 moles) in one lot. Further the reaction mixture was stirred at room temperature for 15-30 min, then refluxed the reaction mixture for 4-5 hrs. The reaction mixture was cooled, dumped into cold water and adjusted to pH-2 using hydrochloric acid. The solid obtained was filtered off, washed with water till neutral, suck dried to obtain 4,6- dihydroxy-5-(2-methoxy phenoxy)[2, 2′]bipyrimidine
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 312613-82-4, Pyrimidine-2-carboximidamide acetate.
Reference:
Patent; CADILA HEALTHCARE LIMITED; SATA, Kaushilk; PANDEY, Bipin; WO2010/32261; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia