Reference of 3029-64-9 ,Some common heterocyclic compound, 3029-64-9, molecular formula is C5Cl3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Under nitrogen protection, 6.28 g (25 mmol) of isopropyl carbazole,2.83 g (10 mmol) of 2,4,6-trichloro-5-cyanopyrimidine, 1.92 g (20 mmol) of NaOBu-t, 1.92 g (0.2 mmol) (t-Bu)3HBF4, 0.09 g (0.1 mmol) Pd2 ( Dba) 3 was added to a 250 ml three-necked flask, 100 ml of toluene was added as a reaction solvent, the temperature was raised to reflux temperature, and the mixture was stirred overnight on a magnetic stirrer. After completion of the reaction, the reaction solution was dried to dryness, and the obtained crude product was purified from petroleum ether and methylene chloride (PE: DCM = 5:1) as a mobile phase. Intermediate 1 was obtained as a white solid powder weighing 4.70 g, yield 73.7percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3029-64-9, its application will become more common.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Gao Wenzheng; Huang Xinxin; Ren Xueyan; (27 pag.)CN109553606; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia