With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine, molecular formula is C10H6Cl2N2, molecular weight is 225.074, as common compound, the synthetic route is as follows.category: pyrimidines
To a 250 mL flask was added a mixture of 5.0 g (22.22 mmol) of Intermediate L-3, 22.09 g (51.1 mmol) of L-6, 7.68 g (55.54 mmol) of potassium carbonate, 1.28 g of Tetrakis (triphenylphosphine) palladium (1.11 mmol) were dissolved in 100 mL of tetrahydrofuran and 30 mL of water, and the mixture was heated under reflux in a nitrogen stream for 10 hours. The resultant mixture was added to 500 mL of methanol, and the crystallized solid was filtered, dissolved in monochlorobenzene, filtered through silica gel / celite, and then an organic solvent was removed in an appropriate amount and then recrystallized from methanol to obtain Compound A-55 (12.68 g, 75% yield). The result of elemental analysis of the resulting Compound A-55 is as follows.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,26032-72-4, 2,4-Dichloro-6-phenylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Samsung SDI Co., Ltd.; Lee, Sung Jae; Kim, Byoung Gu; Kim, Young Kwan; Min, Soo Hyoun; Saw, Ju Hee; Yun, Uhn Son; (42 pag.)KR2016/19747; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia