Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 63200-54-4
Step 1: preparation of tert-butyl 3-(((2-chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)amino)methyl)azetidine-1-carboxylate (0266) (0267) 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (360 mg, 1.92 mmol) and tert-butyl 3-(aminomethyl)azetidine-1-carboxylate (374 mg, 2.01 mmol) were dissolved in methanol (20 mL), followed by the addition of N,N-diisopropylethylamine (667 muL, 3.83 mmol) under stirring at room temperature. The reaction solution was refluxed for 3 hours, and then concentrated, re-dissolved in dichloromethane (50 mL), washed with water (30 mL) and concentrated to give a white solid (350 mg). Yield: 51.2%. MS (ESI, m/z): [M+H]+: 338.2.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 63200-54-4, 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine.
Reference:
Patent; Beijing Hanmi Pharmaceutical Co., Ltd.; LIU, Jinming; CHA, Mi Young; LI, Gong; LI, Zhanmei; QIU, Hongjuan; KIM, Maengsup; (104 pag.)EP3048105; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia