Reference of 13544-44-0 , The common heterocyclic compound, 13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(S)-3-(l-Aminoethyl)-8-(l-methyl-lH-pyrazol-4-yl)-2-phenylisoquinolin-l(2H)-one (63) (570 mg, 1.66 mmol), 2,4-dichloro-5-iodopyrimidine (455 mg, 1.66 mmol) and DIEA (0.27 mL, 1.66 mmol) were dissolved in n-butanol (12 mL) in a sealed tube, and the resulting mixture was stirred at 100 C for 16 h. The mixture was allowed to cool to RT, quenched with water and extracted with ethyl acetate (150 mL x 2). The combined organic layers were washed with brine, dried over Na2SC>4 and filtered. The filtrate was concentrated in vacuo to afford the product (S)-3-(l- ((2-chloro-5 odopyrimidin-4-yl)amino)ethyl)-8-(l-methyl-lH-pyrazol-4-yl)-2-phenylisoquinolin-l(2H)-one (64) as an oil. The product obtained was used in the next step without purification. ESI-MS m/z: 583.0 [M+H]+.
The synthetic route of 13544-44-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INTELLIKINE, INC.; INFINITY PHARMACEUTICALS, INC.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; CASTRO, Alfredo, C.; EVANS, Catherine, A.; WO2011/146882; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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