Reference of 114969-66-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 114969-66-3, name is 5-Bromo-4-cyanopyrimidine, molecular formula is C5H2BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 41A Ethyl 3-aminothieno[3,2-d]pyrimidine-2-carboxylate 5-Bromo-4-cyanopyrimidine (2.10 g, 11.4 mmol), prepared by the method of Yamanaka, et al., Chem. Pharm. Bull., 35:3119 (1987), was treated with 1.38 g (11.5 mmol) ethyl thioglycolate and 1.21 g (11.4 g) sodium carbonate in 36 ml of refluxing ethanol. After 3 hours, the reaction mixture was cooled to room temperature, quenched with water and concentrated. The residue was purified by column chromatography on silica gel eluding first with 4:1 then 1:1 hexanes: ethyl acetate to give 1.10 g (43%) of the title compound, mp 139-141 C. 1 H NMR (300 MHz, CDCl3) delta 1.42 (t, 3H), 4.41 (q, 2H), 6.17 (br s, 2H), 9.19 (s, 1H), 9.20 (s, 1H). MS (DCI/NH3) m/e 224 (M+H)+, 241 (M+NH4)+.
According to the analysis of related databases, 114969-66-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Abbott Laboratories; US5597823; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia