The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Computed Properties of 2927-71-1.
Eberl, H. Christian;Werner, Thilo;Reinhard, Friedrich B.;Lehmann, Stephanie;Thomson, Douglas;Chen, Peiling;Zhang, Cunyu;Rau, Christina;Muelbaier, Marcel;Drewes, Gerard;Drewry, David;Bantscheff, Marcus research published 《 Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells》, the research content is summarized as follows. Kinobeads are a set of promiscuous kinase inhibitors immobilized on sepharose beads for the comprehensive enrichment of endogenously expressed protein kinases from cell lines and tissues. These beads enable chemoproteomics profiling of kinase inhibitors of interest in dose-dependent competition studies in combination with quant. mass spectrometry. We present improved bead matrixes that capture more than 350 protein kinases and 15 lipid kinases from human cell lysates, resp. A multiplexing strategy is suggested that enables determination of apparent dissociation constants in a single mass spectrometry experiment Miniaturization of the procedure enabled determining the target selectivity of the clin. BCR-ABL inhibitor dasatinib in peripheral blood mononuclear cell (PBMC) lysates from individual donors. Profiling of a set of Jak kinase inhibitors revealed kinase off-targets from nearly all kinase families underpinning the need to profile kinase inhibitors against the kinome. Potently bound off-targets of clin. inhibitors suggest polypharmacol., e.g. through MRCK alpha and beta, which bind to decernotinib with nanomolar affinity.
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Computed Properties of 2927-71-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia