Dolman, Nigel P. published the artcileSynthesis and Pharmacology of Willardiine Derivatives Acting as Antagonists of Kainate Receptors, COA of Formula: C5H6N2O2, the publication is Journal of Medicinal Chemistry (2005), 48(24), 7867-7881, database is CAplus and MEDLINE.
The natural product willardiine, I (R = H), is an AMPA receptor agonist while 5-iodowillardiine, I (R = I), is a selective kainate receptor agonist. In an attempt to produce antagonists of kainate and AMPA receptors, analogs of willardiine with substituents at the N3 position of the uracil ring were synthesized. The N3-4-carboxybenzyl substituted analog II (Ar = C6H4CO2H-4) was found to be equipotent at AMPA and GLUK5-containing kainate receptors in the neonatal rat spinal cord. The N3-2-carboxybenzyl substituted analog II (Ar = C6H4CO2H-2) proved to be a potent and selective GLUK5 subunit containing kainate receptor antagonist when tested on native rat and human recombinant AMPA and kainate receptor subtypes. The GLUK5 kainate receptor antagonist activity was found to reside in the S-enantiomer III (R = H) whereas its R enantiomer was almost inactive. 5-Iodo-substituted derivative III (R = I) was found to have enhanced potency and selectivity for GLUK5.
Journal of Medicinal Chemistry published new progress about 608-34-4. 608-34-4 belongs to pyrimidines, auxiliary class Pyrimidine,Amide, name is 3-Methylpyrimidine-2,4(1H,3H)-dione, and the molecular formula is C5H6N2O2, COA of Formula: C5H6N2O2.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia