The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methylfuran-2(3H)-one(SMILESS: O=C1OC(C)=CC1,cas:591-12-8) is researched.Synthetic Route of C5H6O2. The article 《Asymmetric vinylogous Michael addition of 5-substituted-furan-2(3H)-ones to an α,β-unsaturated-γ-lactam》 in relation to this compound, is published in Organic & Biomolecular Chemistry. Let’s take a look at the latest research on this compound (cas:591-12-8).
The manuscript describes an utilization of 5-substituted-furan-2(3H)-ones as pronucleophiles in an asym. vinylogous Michael addition to an α,β-unsaturated-γ-lactam, thus leading to hybrid mols. possessing γ-lactam and butenolide structural motifs. The transformation utilizes two potentially vinylogous pronucleophiles and has been realized by simultaneous activation of both substrates by a bifunctional organocatalyst derived from a cinchona alkaloid. Reaction occurs in a highly enantio- and diastereoselective manner and the synthetic potential of the target products has been confirmed in stereoselective transformations.
Here is just a brief introduction to this compound(591-12-8)Application In Synthesis of 5-Methylfuran-2(3H)-one, more information about the compound(5-Methylfuran-2(3H)-one) is in the article, you can click the link below.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia