In 1971,Journal of Medicinal Chemistry included an article by Cohen, Sasson; Ashani, Yacov. COA of Formula: C5H5N3O. The article was titled 《Nucleophilicity of some reactivators of phosphorylated acetylcholinesterase. 5》. The information in the text is summarized as follows:
Reactivation of diisopropyl phosphorofluoridate-inactivated acetylcholinesterase by 14 heterocyclic oximes, was related with the nucleophilicity and basicity of these oximes. The value of kr (the 1st-order rate constant) at pH 7.4 was a function of both the nucleophilicity of the reactor mol., and its basicity, reaching an optimum for compounds with a pKa value in the range of 7.6-8.0, e.g., 1-methyl-4-formylrimidinium oxime iodide (I). The experimental process involved the reaction of Pyrimidine-4-carbaldehyde oxime(cas: 1073-65-0COA of Formula: C5H5N3O)
Pyrimidine-4-carbaldehyde oxime(cas: 1073-65-0) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.COA of Formula: C5H5N3O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia