The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. SDS of cas: 2927-71-1.
Chen, Xiaojing;Liu, Lu;Liu, Peng;Chen, Yingying;Lin, Dan;Yan, Hao;Yan, Qi;Wang, Yi;Qiu, Yinda;Fang, Bo;Huang, Huijing;Qian, Jianchang;Zhao, Yunjie;Du, Zhou;Zhang, Qianwen;Li, Xiaokun;Zheng, Xiaohui;Liu, Zhiguo research published 《 Discovery of Potent and Orally Bioavailable Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for the Treatment of Osteosarcoma》, the research content is summarized as follows. Herein design, synthesis and structure-activity relationships of novel pyrimidine-2,4-diamine derivatives I [R1 = H, CF3, Me; R2 = F, Cl, Me, etc.; R1R2 = CH=CH-S], I [R4 = H, 2-OMe, 3-OMe, etc.; R5 = (indol-5-yl), (indol-4-yl), (1-methyl-1H-indol-5-yl), etc.], III [R4 = H, 2-OMe, 3-OMe, etc.; R5 = indazol-6-yl, (4-ethylpiperazin-1-yl), (indazol-6-yl), etc.] that selectively inhibit PDGFRα/β kinases was studied. The screening cascades revealed that I [R4 = 3-OMe; R5 = (4-Ethylpiperazin-1-yl)] was the preferred compound among these derivatives, with IC50 values of 2.4 and 0.9 nM for PDGFRα and PDGFRβ, resp. Moreover, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) experiment revealed that I [R4 = 3-OMe; R5 = (4-ethylpiperazin-1-yl)] has a substantial cytotoxic effect against all osteosarcoma cancer cell lines; I [R4 = 3-OMe; R5 = (4-Ethylpiperazin-1-yl)] also displayed robust antitumor effects and low toxicity in a xenograft model. Addnl., I [R4 = 3-OMe; R5 = (4-ethylpiperazin-1-yl)] showed excellent bioavailability (F = 62.9%), suitable half-life (T1/2 = 2.12 h), satisfactory metabolic stability, and weak CYP isoform inhibitory activity, suggesting that I [R4 = 3-OMe; R5 = (4-ethylpiperazin-1-yl)] was a potential drug candidate for PDGFR-driven osteosarcoma.
2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., SDS of cas: 2927-71-1
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia